Monday, November 20, 2017

Progesterone to fight preterm birth

progesterone and preterm birth
via micro.magent.fsu.edu
"A new study published today (17.11.17) -- World Prematurity Day -- in the American Journal of Obstetrics & Gynecology provides additional support for treatment with vaginal progesterone to reduce the risk of preterm birth, neonatal complications and infant death in pregnant women with a short cervix. A shortened cervix is the most powerful predictor of preterm birth.

A meta-analysis of individual patient data by researchers at the Perinatology Research Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the Wayne State University School of Medicine and the Detroit Medical Center, further validates the use of vaginal progesterone to decrease the risk of preterm birth and improve perinatal outcomes in women with a single pregnancy found via sonography to have a short cervix. Vaginal progesterone therapy to reduce preterm birth was developed at the PRB in 2011.

The findings are welcome news in the fight against preterm birth, the leading cause of death in children younger than 5. The March of Dimes annual report on preterm birth for 2017 indicates that the rate of preterm birth in the United States climbed for the second consecutive year in 2016 after nearly a decade of decline.

The 2017 March of Dimes Premature Birth Report Card provides preterm birth rates and grades for all 50 states, plus the District of Columbia and Puerto Rico, based on birth data from the National Center for Health Statistics. The latest report card puts the national preterm birth rate at 9.8 percent (a C grade), an increase from the rate of 9.6 percent in 2015. Preterm birth rates worsened in 43 states, the District of Columbia and Puerto Rico. Only four states received an A grade. Michigan, with its 10.1 percent rate, ranked worse than 26 states and received a C grade..."

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