Friday, June 16, 2017

Follistatin is a key player in embryo implantation

embryo implantation and follistatin
via primitive-streak.org
"Looking to improve the success rate of assisted reproductive technologies, researchers at Baylor College of Medicine investigated in more detail the mechanism involved in successful embryo implantation, an essential component of female fertility. They discovered that the protein follistatin plays a key role in establishing receptivity of the uterus to embryo implantation in an animal model. 

The results, published in the Proceedings of the National Academy of Sciences, contribute to the understanding of embryo implantation and provide an animal model in which to study human embryo implantation failure.

"Embryo implantation into the uterus wall is a highly coordinated process that involves many proteins and communication between the embryo and the mother. If this communication fails, the embryo won't attach to the uterus and a new life won't develop," said co-author Dr. Diana Monsivais, postdoctoral fellow in pathology & immunology at Baylor College of Medicine.

The complex process of embryo implantation in the uterus has raised interest among researchers in the field in part because it fails in about half of in vitro fertilization procedures. A better understanding of the process would help raise the odds of successful attempts at in vitro fertilization..."

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