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| credit: Esben Lorentzen |
"Molecular motors produce the force that powers the beat of sperm cell tails to generate movement toward the egg cell for fertilization. New research now shows how the molecular motors that power the movement of sperm cells are recognized and specifically transported into the tail region of the cell. This knowledge can pave the way for a better understanding of disease causing mutations causing sterility.
Molecular motors use the molecule ATP as energy source to organize the inner life of cells. Dyneins are the largest and most complex molecular motors and are responsible for intracellular transport and for generation of the force required for motility of cilium organelles. Cilia are thin structures found on the surface of our cells where they function as sensors receiving signals from the environment and as motors causing the cell or the environment to move.
Motile cilia are found as a single copy on sperm cells and in multiple copies on cells in our lungs where they generate a fluid flow necessary for the removal of dust particles and pathogens from the airways. The large dynein motors (known as 'outer dynein arms´, ODA) -- that are necessary for the motility of cilia -- are actively transported into cilia via the intraflagellar transport (IFT) system and the transport adaptor ODA16. Mutations in dynein motors or IFT factors can result in infertility and respiratory deficiency..."
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