Showing posts with label newborns. Show all posts
Showing posts with label newborns. Show all posts

Monday, March 5, 2018

Newborn babies who suffered stroke regain language function in opposite side of brain

newborns stroke and language function
image credit: annahusrtphotography.com
"It's not rare that a baby experiences a stroke around the time it is born. Birth is hard on the brain, as is the change in blood circulation from the mother to the neonate. At least 1 in 4,000 babies are affected shortly before, during, or after birth.

But a stroke in a baby—even a big one—does not have the same lasting impact as a stroke in an adult. A study led by Georgetown University Medical Center investigators found that a decade or two after a "perinatal" stroke damaged the left "language" side of the brain, affected teenagers and young adults used the right sides of their brain for language.

The findings, to be reported Feb. 17 in a symposium at the American Association for the Advancement of Science (AAAS) Annual Meeting in Austin, Tex., demonstrates how "plastic" brain function is in infants, says cognitive neuroscientist Elissa L. Newport, PhD, professor of neurology at Georgetown University School of Medicine, and director of the Center for Brain Plasticity and Recovery at Georgetown University and MedStar National Rehabilitation Network.

Her study found that the 12 individuals studied, aged 12 to 25, who had a left-brain perinatal stroke all used the right side of their brains for language. "Their language is good—normal," she says.

The only telltale signs of prior damage to their brain are that some study individuals limp a bit and many have learned to make their left hands dominant because the stroke left right hand function impaired. They also have some executive function impairments—slightly slower neural processing, for example—that are common in individuals with brain injuries. But basic cognitive functions, like language comprehension and production, are excellent, Newport says..."

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Monday, November 13, 2017

Working to reduce brain injury in newborns

newborn and brain injuries,treatmnet to reduce brain injuries in newborns
via medicalexpress.com
"Research-clinicians at Children's National Health System led the first study to identify a promising treatment to reduce or prevent brain injury in newborns who have suffered hypoxia-ischemia, a serious complication in which restricted blood flow deprives the brain of oxygen.

Consequences of brain injury resulting from oxygen deprivation affect the entire lifespan and range from mild (learning disabilities) to severe (inability to breathe, walk, talk or see). This complication can occur during or before birth due to maternal/placental problems, such as placental abruption or cord prolapse, or due to fetal/newborn issues, such as asphyxia due to labor difficulties, infection, fetal-maternal bleeding or twin-to-twin transfusion.

Published in Neonatology on Oct. 13, 2017, the study evaluated newborn experimental models exposed to hypoxia-ischemia. The experimental models were given standard cooling therapy (therapeutic hypothermia) alone and in combination with a selective Src kinase inhibitor, PP2, that blocks a regulatory enzyme of apoptosis (cell death), which intensifies as a result of hypoxia-ischemia. The Food and Drug Administration has approved a Src kinase inhibitor as an oncology treatment. This study is the first to test the benefits of blocking this enzyme in reducing the neurological damage caused by brain hypoxia-ischemia.

"In hypoxia-ischemia, CaM kinase is over-activated, but hypothermia has been shown to decrease this enzyme's activation. We theorized that a Src kinase inhibitor, in addition to hypothermia, would further attenuate the activation of CaM kinase IV and that the result might be less brain damage," explains Panagiotis Kratimenos, M.D., Ph.D., the study's lead author, and a specialist in neonatology and neonatal neurocritical care at Children's National. "From this study, we were pleased that this seems to be the case."

The research team assessed neuropathology, adenosine triphosphate and phosphocreatine concentrations as well as CaM kinase IV activity. The CaM kinase IV activity in cerebral tissue was 2,002 (plus or minus 729) with normal oxygen levels and in normal temperatures, 4,104 (plus or minus 542) in hypoxia with hypothermia treatment, and 2,165 (plus or minus 415) in hypoxia with hypothermia treatment combined with PP2 administration..."

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