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| via ycmhz.com |
"Potentized estrogen is an effective treatment for reducing endometriosis-associated pelvic pain (EAPP) that has been refractory to conventional hormone therapy, according to the results of a randomized, double-blind, placebo-controlled study reported by researchers from Brazil.
Potentized estrogen is an oral preparation of 17-beta estradiol in the 12cH, 24cH and 18cH potencies formulated in an alcohol solution.2 The homeopathic treatment was investigated in a trial that included 50 women who were randomized into 2 groups to receive 3 drops twice daily of potentized estrogen or placebo alcohol solution.
To be eligible for participation, women had to be between18 and 45 years old and diagnosed with deeply infiltrating endometriosis confirmed by magnetic resonance imaging, transvaginal ultrasound after bowel preparation, or laparoscopy. In addition, they needed to have chronic pelvic pain refractory to conventional hormone treatment and a score ≥5 on an 11-point (range 0 to 10) visual analogue scale of EAPP.
Changes from baseline to week 24 in the EAPP global score and in each of its 5 components (dysmenorrhea, dyspareunia, noncyclic pelvic pain, cyclic bowel pain, and cyclic urinary pain) were analyzed as the primary efficacy endpoint. The results showed women treated with potentized estrogen had statistically significant reductions in the global EAPP and in the component scores for dysmenorrhea, noncyclic pelvic pain, and cyclic bowel pain. In the control group, neither the EAPP global score nor any of the component scores were significantly changed from baseline at week 24.
Changes in the 36-Item Short-Form Health Survey (SF-36), depression symptoms assessed with the Beckman Depression Inventory, and anxiety symptoms measured using the Beck Anxiety Inventory were analyzed as secondary endpoints. Statistically significant improvements occurred only among women in the potentized estrogen group and were seen in three of eight SF-36 domains (bodily pain, vitality, and mental health) and in the Beckman Depression Inventory..."
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