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Source: European Society of Human Reproduction and Embryology | Summary: Women who are overweight or obese pose an ongoing challenge for the fertility clinic. Many studies show that these patients are at increased risk of infertility and are less likely than normal-weight women to conceive after fertility treatment.
"Women who are overweight or obese pose an ongoing challenge for the fertility clinic. Many studies show that these patients are at increased risk of infertility and are less likely than normal-weight women to conceive after fertility treatment.
For example, ovulating sub-fertile women with a body mass index (BMI) of 29 kg/m2 or higher have been found in one study to have a 4% lower pregnancy rate per kg/m2 increase per year, compared to ovulatory subfertile women with a BMI below 29. Such studies suggest that weight reduction will increase the chances of conception, decrease pregnancy complications and improve perinatal outcome; however these results have not been confirmed in large randomised controlled trials.
The first major trial assessing the effect on fertility of lifestyle adjustment in obese women was published earlier this year and found that a weight-loss intervention preceding fertility treatment did not result in higher rates of healthy singleton birth within 24 months.(1)
In this study -- the LIFEstyle study performed in the Netherlands -- 290 women were assigned to a 6-month lifestyle-intervention programme preceding 18 months of infertility treatment (intervention group) while 287 women were assigned to prompt infertility treatment over the same 24 month study period (control group).
Mean weight loss was 4.4 kg in the intervention group and 1.1 kg in the control group, but delivery rates were comparable in both groups, taking into account pregnancies conceived within but ending beyond the 24-month follow-up period..."
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