Source:Taylor & Francis | Summary:Ovarian tissue cryopreservation (OTC), harvesting and freezing ovarian tissue, is the most promising complication-free strategy to preserve potential fertility in pre-pubescent girls undergoing sterilizing chemotherapy, according to a 13 year study.
"Ovarian tissue cryopreservation (OTC), harvesting and freezing ovarian tissue, is the most promising complication-free strategy to preserve potential fertility in pre-pubescent girls undergoing sterilising chemotherapy, according to a 13 year study by Fanny Chambon et al. in the journal, Human Fertility.
Almost 80% of children and adolescents currently treated for cancer or leukemia will be long term survivors. Paediatric oncologists are concerned that side effects such as low fertility, infertility and early menopause can reduce the quality of life for survivors. Indeed, in females, cancer treatments can result in premature ovarian insufficiency (POI).
Therefore, preserving fertility in young girls is becoming a key issue for improving quality of life. However, only a few teams performing OTC in children have reported on their practice.
The paper reports on 13 years' experience of ovarian tissue cryopreservation before sterilising treatment. The aim of the study on OTC in 36 girls at risk of early menopause, aged between 2 and 19 years old, at the Clermont-Ferrand City Paediatric Oncology Department is to assess how effective, feasible and risky this treatment is..."
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