Source: Queen's University | Summary: A promising method of treating male infertility using a synthetic version of the sperm-originated protein known as PAWP has been developed by researchers. The research promises to diagnose and treat cases of male factor infertility where a patient's sperm is unable to initiate or induce activation of the egg to form an early embryo.
"Queen's University researcher Richard Oko and his co-investigators have come up with a promising method of treating male infertility using a synthetic version of the sperm-originated protein known as PAWP.
They found this protein is sufficient and required to initiate the fertilization process.
Dr. Oko's research promises to diagnose and treat cases of male factor infertility where a patient's sperm is unable to initiate or induce activation of the egg to form an early embryo.
"PAWP is able to induce embryo development in human eggs in a fashion similar to the natural triggering of embryo development by the sperm cell during fertilization," explains Dr. Oko (Biomedical and Molecular Sciences). "Based on our findings, we envision that physicians will be able to improve their diagnosis and treatment of infertility, a problem that affects 10 to 15 per cent of couples worldwide."
The results of this study highlight the potential clinical applications of sperm PAWP as a predictor of infertility treatment. Since most human infertility treatments are now done by injecting a single sperm directly into an egg, supplementation of human sperm with PAWP protein may potentially be used to improve the success rate of infertility treatments in the future..."
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