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"Premature births are intimately linked with inflammation of the uterine tissue, that induces contractions and preterm labour.
In their search for a mean to prevent this phenomenon and complications related to deliveries occurring before 37 weeks of gestation, researchers at CHU Sainte-Justine and University of Montreal discovered an agent that shows efficacy in inhibiting inflammation and preventing or delaying uterine contractions and premature delivery in murine models – without adversely affecting the foetus or the mother.
This discovery is a giant step towards preventing prematurity, which is the world’s leading cause of infant death and the origin of potentially severe, long-lasting physical, intellectual or psychological impairment for the 10 per cent of infants born preterm worldwide.
While examining uterine tissues, the scientists found a messenger, called Interleukin 1, to be responsible for triggering and amplifying inflammation in the uterus, which led them to run preclinical trials in which they tested therapeutic agents known to target that messenger..."
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